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Aplastic Anemia (Bone Marrow Failure - Toxicity) in Dogs

Aplastic Anemia (Bone Marrow Failure - Toxicity) in Dogs - Dogs Health care Articles

Aplastic Anemia (Bone Marrow Failure - Toxicity) in Dogs : Dogs Health care Articles; Anemia is defined as a reduction in the normal number of red blood cells. All types of blood cells originate in the bone marrow, so healthy bone marrow will respond to a low blood cell count by producing more. If the body is unable to adequately generate replacement blood cells, ... Aplastic Anemia (Bone Marrow Failure - Toxicity) in Dogs


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Aplastic Anemia (Bone Marrow Failure - Toxicity) in Dogs

Aplastic Anemia (Bone Marrow Failure - Toxicity) in Dogs

Anemia is defined as a reduction in the normal number of red blood cells. All types of blood cells originate in the bone marrow, so healthy bone marrow will respond to a low blood cell count by producing more. If the body is unable to adequately generate replacement blood cells, this is called non-regenerative anemia. Aplastic Anemia (Bone Marrow Failure - Toxicity) in Dogs

Aplastic anemia in dogs is a diseased condition resulting from the bone marrow's inability to replenish blood cells. Where aplastic refers to the dysfunction of an organ, and anemia refers to a lack of red blood cells. Aplastic anemia is a life-threatening condition resulting when normal bone marrow is replaced by adipose (fat) tissue, thus preventing it from releasing the required number of WBCs, RBCs, and platelets and resulting in an overall decrease in the total number of these cells in the blood. RBCs have several vital functions in the body, including carriage of oxygen and removal of waste carbon dioxide. WBCs are essential for fighting infections and foreign particles, whereas platelets are required for clotting the blood and preventing hemorrhage. All symptoms seen in aplastic anemia directly relate to the functions of these cells. In most cases of aplastic anemia, all three types of cells are affected. If left untreated, this condition can lead to death in severely affected dogs.

Symptoms and Types

All three types of cells affected in this disease have different roles to play in normal body functions, therefore, the symptoms will vary depending on the type of cells mostly affected and the severity of the problem. Following are some of the symptoms related to aplastic anemia.
Poor Appetite Weight loss Lethargy Lack of stamina Weakness Rapid heart rate (tachycardia) Rapid breathing (tachypnea) Paleness of the mucus membranes, especially notable around the gums Blood in the stool Petechiation (a purplish spot on the surface of the skin) Fever Vomiting Diarrhea Disorientation Lack of coordination Seizures
  • Vomiting
  • Diarrhea
  • Recurrent infections
  • Poor Appetite
  • Weight loss
  • Lethargy
  • Lack of stamina
  • Weakness
  • Rapid heart rate (tachycardia)
  • Rapid breathing (tachypnea)
  • Paleness of the mucus membranes, especially notable around the gums
  • Blood in the stool
  • Petechiation (a purplish spot on the surface of the skin)
  • Fever
  • Disorientation
  • Lack of coordination
  • Seizures


Causes

There are a variety of causes for aplastic anemia, including infections, toxins, drugs, and chemicals which may cause aplastic anemia in dogs. Following are some major causes of aplastic anemia in dogs:
  • canine parvovirus
  • ehrlichiosis
  • chemotherapy drugs
  • Some types of antibiotics
  • estrogen administration
  • methimazole (usually used for hyperthyroid drug)
  • fenbendazole (usually used for roundworm treatment)
  • phenylbutazone drugs
  • Other factors
  • Toxin ingestion
  • Cancerous tumor in another part of the body
  • Radiation therapy
  • Autoimmune response
  • Hereditary
  • Idiopathic (with no clear reason)

Diagnosis

You will need to give a thorough history of your dog's health and onset of symptoms. Your veterinarian will perform a physical examination with full laboratory testing, including complete blood tests, biochemical profiles, and urinalysis. The results of these tests will provide valuable information for the preliminary diagnosis. The count of various cells will be determined; counts that are far below the normal ranges are considered a positive result.

Your veterinarian will also evaluate your dog for the presence of any infectious diseases, but the most valuable test in the diagnosis of aplastic anemia is bone marrow sampling. In this test a small sample of bone marrow will be collected through aspiration or biopsy. The microscopic studies will reveal the important information related to the architecture of the bone marrow and any develop

ental problems of the various cells in the bone marrow.


Treatment

Your veterinarian will start treating your dog immediately after a confirmatory diagnosis has been made. Your dog may need to be hospitalized for few days to be monitored and treated. With aplastic anemia, there are number of problems to deal with and supportive therapy will be initiated to provide the required nutrition and energy that your dog is lacking. If required, whole blood transfusions may be recommended for severely anemic patients. As this problem is mediated mostly through the immune system, the primary treatment involves suppressing the immune system with drugs like cyclosporine A. Cyclosporine and other related agents suppress the bone marrow’s over-response. Drugs supporting the bone marrow functions are also recommended for these patients. Antibiotics are given to treat ongoing infections as well as for the prevention of further infections.

Living and Management

During hospitalization, your veterinarian will monitor your dog's status daily. Blood tests will be repeated to determine the current status of the problem. In some dogs, bone marrow sampling may need to be repeated in order to see if the bone marrow is responding normally or not. Unfortunately, with aplastic anemia few patients survive despite extensive care and treatment. Young dogs have a better chance of survival, but even if initial recovery is attained, it may take several weeks to months for a complete recovery.



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Sources :
- Some parts taken from Pedmd.com


Aplastic Anemia (Bone Marrow Failure - Toxicity) in Dogs

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