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Paraproteinemia : Abnormal Protein Production in Dogs , Symptoms , Diagnosis and Treatment

Paraproteinemia : Abnormal Protein Production in Dogs , Symptoms , Diagnosis and Treatment - Dogs Health care Articles

Paraproteinemia : Abnormal Protein Production in Dogs , Symptoms , Diagnosis and Treatment : Dogs Health care Articles; White blood cells produce large quantities of antibodies, essential to the body's immune response to invasions of bacteria and viruses. " src="http://gallery2.vetarena.net/image-1030.m.jpg" /> Antibodies AKA immunoglobulins, small protein molecules found in the blood or other body fluids and used by the immune system to fight against foreign substances, such as ... Paraproteinemia : Abnormal Protein Production in Dogs , Symptoms , Diagnosis and Treatment


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Paraproteinemia : Abnormal Protein Production in Dogs , Symptoms , Diagnosis and Treatment

Paraproteinemia : Abnormal Protein Production in Dogs , Symptoms , Diagnosis and Treatment

White blood cells produce large quantities of antibodies, essential to the body's immune response to invasions of bacteria and viruses. Paraproteinemia : Abnormal Protein Production in Dogs , Symptoms , Diagnosis and Treatment Antibodies AKA immunoglobulins, small protein molecules found in the blood or other body fluids and used by the immune system to fight against foreign substances, such as bacteria, viruses, fungus, or cancer cells.
In paraproteinemia, abnormal proteins called paraprotein (proteins in the blood or urine), or M component, are produced by a single clone (group) of plasma cells. Such production of abnormal proteins is commonly seen in plasma cell tumors and may also be seen in some other types of tumors. This condition is usually seen in middle-aged to older dogs.

Symptoms of Paraproteinemia in Dogs

Symptoms of Paraproteinemia in Dogs may include :
  • Seizures
  • Lethargy
  • Lameness
  • Nose bleed
  • Generalized weakness
  • Blindness
  • Memory loss
  • Increased thirst and urination

Diagnosis of Paraproteinemia in Dogs

The history of dog's health , onset of symptoms, and possible incidents that might have led to this condition will be required, like infections, or contact with carcinogenic substances. The Veterinarian will perform a complete physical examination, including routine laboratory testing. A complete blood profile will be conducted, including a chemical blood profile, a complete blood count, and a urinalysis. Blood testing may reveal anemia, abnormally low levels of leukocytes or white blood cells (leukopenia), or abnormally low levels of platelets (thrombocytopenia).
A biochemistry profile may show abnormally high levels of proteins in the blood, low levels of albumin (a type of protein), abnormally high levels of calcium (hypercalcemia), and high levels of urea and creatinine in the blood. The urinalysis may show the presence of protein in the urine (proteinuria). More specific testing will also be conducted to diagnose various diseases.
Thoracic and abdominal X-rays will be taken to identify where lymphoma is present. A sample of bone marrow may be taken, which will reveal more details associated with this disease. Similarly, samples from affected lymph nodes will also be taken to identify the type of cancer cells or infectious agents that are attacking the body.

Causes of Paraproteinemia in Dogs

Possible causes of Paraproteinemia in Dogs may include :
  • Viral Infections
  • Cancers
  • Exposure to carcinogens (like paints or solvents)
  • Genetic predisposition

Treatment of Paraproteinemia in Dogs

If a dog is diagnosed with paraproteinemia and associated cancer, treatment may include chemotherapy, radiation therapy, or any other remedies recommended by your veterinary oncologist. Antibiotic therapy may also be conducted to treat underlying bacterial infections, if present.

Home Care and management of Paraproteinemia in Dogs

Veterinarian's guidelines for chemotherapy medication should be followed at home, as these drugs are potentially toxic and should only be used under strict guidance from a veterinary oncologist.

How to Prevent Paraproteinemia in Dogs

Since this disease is caused by an underlying cancer it is almost not preventable and limiting the exposure to carcinogens such as paints or solvents would be the only prevention.



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Source :
- Some Parts are taken from PetMD.com
- Image : From Google


Paraproteinemia : Abnormal Protein Production in Dogs , Symptoms , Diagnosis and Treatment

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